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Defender:
Ms Maria Eugenia Ibanez Perez-Zamacona
Title of PhD dissertation: Bioanthropology of Obesity in a population
of the Autonomous Community of the Basque Country
Affiliation: University of The Basque Country (UPV/EHU), Faculty
of Science and Technology, Department of Genetics, Physical Anthropology
and Animal Physiology
Supervisor: Prof. Esther Rebato
Date of PhD defence: 18.09.2017
Obesity has become a major
health concern worldwide due to its increasing prevalence and its detrimental
health impact. Common obesity is a widespread condition in westernized
countries; however, its incidence is variable between and within populations.
Therefore, it is of great importance to study obesity in many different
populations to help understand the underlying causes of this condition.
Obesity development is influenced by many modifiable and non-modifiable
factors. Genetic profile, sex, age and environmental factors such as
lifestyle (e.g. sleep patterns, physical activity), socioeconomic status
(e.g. education, professional occupation) or psychological circumstances
(e.g. body image perception and satisfaction) are considered key elements
in obesity development, as they are involved in energy balance and adiposity
accumulation. The overarching aim of the present thesis was to study
the aetiology of obesity from anthropological, psychological, environmental
and genetic perspectives in a population residing in the Basque Country
(Spain). The general hypothesis of this research was that genetic factors,
sex, age, environmental and psychological factors influence adiposity
and energy expenditure and in turn are significantly associated with
several phenotypes of overweight and obesity in the Basque Country population.
The main objective was to explore the role of different modifiable and
non-modifiable factors in obesity aetiology from a bioanthropological
approach. To achieve this major purpose some key factors, including
body morphology and composition, body image, environmental context,
and genetic profile were analysed and discussed in relation to obesity,
in an adult sample (524 unrelated individuals, 320 women and 204 men)
from the Basque Country population, based in a case-control design.
First, the relationship between body morphology and composition (assessed
through the somatotype components) and different nutritional categories
was studied. The results of these analyses showed that not only fat
mass but also fat free mass increase in obesity development. Changes
in body composition and morphology also entail changes in body image,
which may influence the perception of the own image, self-esteem and
attitudes towards it. The present thesis shows that body image perception
is strongly related to nutritional status both in men and women. However,
in general women desired to be thinner while men desired bigger body
frames. Lifestyle changes in modern society (increase consumption of
energy dense food and decrease physical activity) have been proposed
as the main factors responsible for the increasing prevalence of obesity
in westernized countries during last decades. Results in this thesis
indicated that physical activity, sleep quality and dietary habits are
predominantly associated with general fat mass while tobacco and alcohol
consumption among others are predominantly associated with fat distribution.
Genetic background is also considered a significant contributor to obesity
risk. Although genetics could not be responsible of obesity epidemic
in the last decades, as genetic background could not be significantly
altered in that time frame, genetic factors strongly influence whether
a person becomes obese or stays slim within a population, at an individual
level. This thesis confirms a modest contribution to obesity of 12 SNPs
in or near NEGR1, TMEM18, GNPDA2, BDNF, UCP2, NRXN3, FTO, KCTD15 and
MAP2K5.
This PhD work was supported
by a grant of the Spanish Ministry of Science and Innovation and by
a pre-doctoral grant of the University of the Basque Country.
Defender:
Ms Veronika Cernanova, RNDr (Rerum Naturalium Doctor)
Title of PhD dissertation: The analysis of polymorphisms in the
genes associated with menopausal status in healthy Slovak women.
Affiliation: Comenius University in Bratislava, Faculty of Natural
Sciences, Department of Anthropology
Supervisor: Prof. Daniela Sivakova
Date of PhD defence: 27.08. 2015
The polymorphisms
of CYP1B1 and COMT genes influence the catalytic properties of enzymes
involved in the metabolism of oestrogens and via that way they alter
steroid hormone levels. All estrogenic-sensitive tissues react on the
changes in the oestrogen concentration; consequently, this affects the
occurrence of menopausal symptoms.
The aim of this dissertation was to examine if polymorphisms in the
oestrogen-metabolizing genes CYP1B1 (Arg48Gly, Ala119Ser, Leu432Val,
Asn453Ser) and COMT (Val158Met) have an impact on the occurrence and
intensity of the menopausal symptoms in the Slovak sample of 40-60 years
old women, and also to investigate possible influence of other factors
(health status, smoking, physical activity, reproductive history, psychical
status) contributing to development of symptoms connected with menopausal
period. The studied sample consisted of 368 women (49.11±5.86);
180 premenopausal (45.06±3.81), 29 perimenopause (49.41±3.94)
and 158 postmenopausal (53.71±4.54) women, respectively. The
CYP1B1 Arg48Gly was associated with hot flushes (p=0,020), feeling of
bloating (p=0.005), palpitation and nervousness (p=0.018), loss of appetite
(p=0.040), feeling of tiredness and exhaustion (p=0.026), lack of energy
(p=0.009), decrease in physical strength (p=0.036) and loss of vitality
(p=0.043). The tree analysis and logistic regression suggested the protective
influence of Gly/Gly genotype against the vasomotor and somatic symptoms
in the pre- and perimenopause and a risk of this genotype during the
postmenopausal period. The analysis also showed the risk of Arg/Arg
genotype for psychological symptoms. The CYP1B1 Ala119Ser was connected
with feeling of bloating (p=0.014), palpitation and nervousness (p=0.006),
involuntary urination while laughing and coughing (p=0.020), feeling
of depression (p=0.048), feeling of tiredness and exhaustion (p=0.011),
lack of energy (p=0.028) and loss of vitality (p=0.005). The statistical
analysis showed a possible protection of Ser/Ser genotype towards the
vasomotor and somatic symptoms in perimenopause and towards psychological
symptoms in postmenopausal, and a risk of this genotype in occurrence
of the vasomotor symptoms in premenopausal women, respectively. The
CYP1B1 Leu432Val was associated with bloating (p=0.045), palpitation
and nervousness (p=0.002), unusual irritation (p=0.018) and intolerance
of others (p=0.032). The tree analysis and logistic regression indicated
the risk of Leu/Leu genotype for the vasomotor, urogenital and psychological
symptoms independent of menopausal status. The CYP1B1 Asn453Ser was
connected with intolerance of other persons (p=0.001), need to be alone
(p=0.014) and feeling unattractive (p=0.032). The statistical analysis
confirms the protection of the Asn/Asn genotype towards the psychological
symptoms. The COMT Val158Met was associated with feeling of bloating
(p=0.034), lack of enjoyment (p=0.027), feeling of depression (p=0.038),
need to be alone (p=0.029), feeling of fear and panic (p=0.043), intolerance
of other persons (p=0.002), anxiety when leaving home (p=0.033), feeling
of tiredness and exhaustion (p=0.044) and decrease in physical strength
(p=0.039). Tree analysis and logistic regression proved the protective
influence of Met/Met towards the occurrence of the psychological symptoms
in pre- and postmenopause and a risk of this genotype in perimenopause
period.
Defender:
Ms Natalia Nowak-Szczepanska
Title of PhD dissertation: Dimorphic changes in body length proportions
during adolescence with respect to biological age
Affiliation: Polish Academy of Sciences, Unit of Anthropology
in Wroclaw, Poland
Supervisor: Assoc. Prof. Slawomir Koziel
Date of PhD defence: 11.05.2015
The aim of the study was qualitative and quantitative assessment of
changes in sexual dimorphism in body length proportions during adolescence
with respect to biological age. Data were collected during Wroclaw Growth
Study. Analyses of body length proportions involved ca. 120 boys and
ca. 120 girls aged 8-18 years. Biological age was defined by the age
of peak height velocity (APHV; Preece-Baines Model 1). Analysis of body
length proportions was conducted in relation to height and trunk length,
separately for lower (lower limbs and their parts) and upper (upper
limbs, their parts, trunk, sitting height) body segment, in both sexes
during adolescence with regard to biological age. Mollison's sexual
dimorphism indexes were assessed for each body length proportion in
subsequent categories of biological age. Due to a longitudinal character
of this study repeated measures analysis of variance was used for the
assessment of changes in body length proportions with respect to biological
age in both sexes. Aforementioned analyses revealed rather moderate
level of sexual dimorphism in length proportions of lower-body segment,
usually in favour of boys relatively to height, but not in all biological
age categories. Nevertheless, for upper-body segment the majority of
body length proportions' indexes showed significantly higher values
in girls (except for relative trunk length in favour of boys), particularly
beginning with APHV. Moreover, changes in body length proportions in
both lower and upper limbs as well as in sitting height and trunk length
significantly reflected growth trajectory of more intense long bones'
growth before APHV and acceleration of the spine development after APHV.
The results of this study considerably fill the gap in the area of changes
in sexual dimorphism in body length proportions during adolescence in
relation to individual growth trajectory with respect to biological
age in boys and girls
Defender: Mr Santiago Rodriguez Lopez
Title of PhD dissertation: Biosocial determinants of healthy
ageing in Spain
Affiliation: Universidad Autonoma de Madrid, Madrid, Spain
Supervisor: Prof. Pilar Montero Lopez
Date of PhD defence: 2014
This dissertation explores biological (physical) and social characteristics
associated with health later in life, integrating gender/sex considerations
and a life course perspective. We use data from 50-years-old and older
Spanish and other European adults from two different sources: the Active
Ageing Longitudinal Study "Estudio Longitudinal de Envejecimiento
Activo" (ELEA) in Spain, and the Survey of Health, Ageing and Retirement
in Europe (SHARE). This study includes cross-sectional and longitudinal
(both prospective and retrospective) designs and embraces a broad set
of variables such as demographic characteristics, socioeconomic and
health indicators, early health and socioeconomic conditions, etc.
Results are presented in five original papers. Cross-sectionally, we
found that, compared to men, part of the overall poorer health among
women was surely determined by a gender effect and may have had an early
origin, probably related to traditional gender roles established early
in life. Additionally, we found marked socioeconomic gradients in health
and mobility indicators like frailty and balance performance. Health
behaviours like physical activity and obesity seemed to play a similar
and small role in explaining the link between socioeconomic status and
frailty and balance in older adults. Longitudinally, in a prospective
study of the predictors of disability for two years, we found that a
decline in function was associated with an increased number of chronic
diseases and symptoms of depression among Spanish men, whereas among
women it was associated with decreased cognitive performance. Finally,
in a retrospective study with a life course approach, we found a direct
association between childhood and adult health among older Europeans,
whereas the impact of the socioeconomic status in childhood was more
indirect and operated through the own socioeconomic status in adulthood.
This suggests that in order to improve adult health, efforts can be
made in ameliorating child health. Moreover, poor childhood health was
a stronger predictor of adult health - having more negative effect -
in Northern compared to other European countries. This finding may be
useful for planning interventions based on country-specific evidence,
and contributes to the understanding of the mechanisms underneath the
health dynamics over the life course.
The results of this study add to the evidence of the importance of including
a multidisciplinary and life course perspective when evaluating health
and well-being in later life. They might also contribute to enhance
health and reduce health inequalities by suggesting effective interventions
meant to improve the quality of life of older adults.
Defender:
Ms Alaitz Poveda
Title of PhD dissertation: Genetic and Environmental Contributions
to Obesity in Roma Population
Affiliation: University of the Basque Country (UPV/EHU), Bilbao,
Spain
Supervisor: Prof. Esther Rebato
Date of PhD defence: 24.01.2013
This PhD work was supported by grants of the Bilbao Bizkaia Kutxa, of
the Spanish Ministry of Science and Innovation, of the Industry Department
of the Basque Government and by a predoctoral grant of the Ministry
of Education of Spain. The most relevant findings of this study have
provided evidence that studied Roma population presents one of the highest
rates of overweight and obesity worldwide which could be partly related
to the generalized underestimation of their actual body size seen among
Roma men and women. Concerning the relationship between adiposity and
blood pressure measurements in Roma population, although these phenotypes
do not seem to share a substantial common genetic background, shared
environmental factors significantly affect the covariation between them.
Waist circumference was the obesity-related trait most genetically correlated
with blood pressure traits which highlight the importance of this measurement
on the determination of the risk of obesity-related diseases. The results
obtained in this research have concluded that lifestyle and socioeconomic
factors have a slight but significant influence on obesity-related traits,
somatotype components and blood pressure phenotypes. Finally, family-based
association tests revealed that SNPs in or near six genes (NEGR1, SH2B1,
BDNF, MC4R, KCTD15 and FAIM2) were significantly associated with body
morphology and obesity-related traits in Roma people.
The tribunal of the thesis was composed by Dr. Rosario Calderon (President,
Universidad Complutense de Madrid), Dr. Daniel Turbón (Universitat
de Barcelona), Dr. Luis Casis (UPV/EHU), Dr. Karri Silventoinen (University
of Helsinki) and Dr. Ana Maria Rocandio (Secretary, UPV/EHU).
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